Rapid Report Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation
نویسندگان
چکیده
Archana Kumari,* Alexandre N. Ermilov,* Benjamin L. Allen,* Robert M. Bradley,* Andrzej A. Dlugosz,* and Charlotte M. Mistretta* Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan; Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan; Department of Molecular and Integrative Physiology, Medical School, University of Michigan, Ann Arbor, Michigan; and Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, Michigan
منابع مشابه
Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation.
Taste sensation on the anterior tongue requires chorda tympani nerve function and connections with continuously renewing taste receptor cells. However, it is unclear which signaling pathways regulate the receptor cells to maintain chorda tympani sensation. Hedgehog (HH) signaling controls cell proliferation and differentiation in numerous tissues and is active in taste papillae and taste buds. ...
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